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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TLK2 All Species: 18.79
Human Site: S177 Identified Species: 41.33
UniProt: Q86UE8 Number Species: 10
    Phosphosite Substitution
    Charge Score: -0.1
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q86UE8 NP_001106178.1 772 87661 S177 G L C F T F V S A Q Q N S P S
Chimpanzee Pan troglodytes XP_523598 848 95816 S275 G L C F T F V S A Q Q N S P S
Rhesus Macaque Macaca mulatta XP_001107302 907 100501 S315 G L C F T F V S A Q Q N S P S
Dog Lupus familis XP_548038 918 102784 S345 G L C F T F V S A Q Q N S P S
Cat Felis silvestris
Mouse Mus musculus O55047 718 82242 Q175 Q I S I Q H R Q T Q S D L T I
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001515053 718 81881 K186 N K N Q D L E K K E G R I D D
Chicken Gallus gallus XP_418070 750 85456 S177 G L C F T F V S A Q Q G S P S
Frog Xenopus laevis
Zebra Danio Brachydanio rerio Q1ECX4 697 79286 S173 A A L E S S K S S D L E K K E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_624065 793 90042 N216 Q V Q V R P T N L S R T S Q V
Nematode Worm Caenorhab. elegans P34314 965 109255 G323 T E Y H Q N Q G S P K R Q P A
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q39238 688 78131 Q164 N N D V T K S Q F V V A P V S
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 88.3 82.3 81.2 N.A. 92.4 N.A. N.A. 68.6 94.1 N.A. 77.9 N.A. N.A. 47.9 36.5 N.A.
Protein Similarity: 100 88.3 83 81.3 N.A. 92.7 N.A. N.A. 77.7 95.8 N.A. 83.9 N.A. N.A. 63.4 50.1 N.A.
P-Site Identity: 100 100 100 100 N.A. 6.6 N.A. N.A. 0 93.3 N.A. 6.6 N.A. N.A. 6.6 6.6 N.A.
P-Site Similarity: 100 100 100 100 N.A. 20 N.A. N.A. 6.6 93.3 N.A. 20 N.A. N.A. 26.6 26.6 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 35.3 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 50.2 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 13.3 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 13.3 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 10 10 0 0 0 0 0 0 46 0 0 10 0 0 10 % A
% Cys: 0 0 46 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 10 0 10 0 0 0 0 10 0 10 0 10 10 % D
% Glu: 0 10 0 10 0 0 10 0 0 10 0 10 0 0 10 % E
% Phe: 0 0 0 46 0 46 0 0 10 0 0 0 0 0 0 % F
% Gly: 46 0 0 0 0 0 0 10 0 0 10 10 0 0 0 % G
% His: 0 0 0 10 0 10 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 10 0 10 0 0 0 0 0 0 0 0 10 0 10 % I
% Lys: 0 10 0 0 0 10 10 10 10 0 10 0 10 10 0 % K
% Leu: 0 46 10 0 0 10 0 0 10 0 10 0 10 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 19 10 10 0 0 10 0 10 0 0 0 37 0 0 0 % N
% Pro: 0 0 0 0 0 10 0 0 0 10 0 0 10 55 0 % P
% Gln: 19 0 10 10 19 0 10 19 0 55 46 0 10 10 0 % Q
% Arg: 0 0 0 0 10 0 10 0 0 0 10 19 0 0 0 % R
% Ser: 0 0 10 0 10 10 10 55 19 10 10 0 55 0 55 % S
% Thr: 10 0 0 0 55 0 10 0 10 0 0 10 0 10 0 % T
% Val: 0 10 0 19 0 0 46 0 0 10 10 0 0 10 10 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 10 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _